Does WINLEVI Cause Purging
Yes, Winlevi can cause purging by increasing the time it takes for your body to produce new skin cells at the bottom layer and shed old, dead skin cells at the topmost layer.
Of course, it is important to understand the difference between purging and breakout. Purging is not a bad thing and it means only that the product is doing what it is supposed to do, getting you rid of the acne.
How Does It Work And Does Winlevi Cause Purging
Winlevi is a topical anti-androgen cream which means that it has to be applied to the skin directly. Now I will tell you how Winlevi cream works. Through your skin, you have androgen receptors, and androgens specifically dihydrotestosterone bind to the receptors on the cells that make up the oil gland which leads to more oil production and more inflammatory mediators.
Androgen receptors are proteins found in cells that bind to androgens, a type of hormone that is present in both men and women. Androgens are involved in the development of sex characteristics of every man, such as facial hair and a deep voice. They also play a role in the production of sebum, an oily substance that is produced by the oil glands in the skin. In the context of acne, high levels of androgens can stimulate the production of sebum and increase inflammation in the skin, leading to the development of acne lesions.
The way Winlevi cream works is that it competes with the dihydrotestosterone for every androgen receptor and that way decreases the oil production and inflammation possibility.
Because it is rapidly metabolized in the skin, it has much fewer effects on your whole body which includes the purging compared to the treatment of acne which includes taking the oral pill spironolactone or an oral contraceptive pill.
Essentially, skin purging is a process by which certain skincare ingredients increase skin cell turnover. And the skin cell turnover is the time it takes for your body to produce new skin cells at the bottom layer and shed old, dead skin cells at the topmost layer.
As I have said before, all of the treatments for acne increase the speed of cell turnover, and that way cause „purging“ of the top layer of the skin.
Does Winlevi Cause More Purging Than Other Treatments?
Winlevi doesn’t cause more purging than any other treatment of acne and as a matter of fact, it has been proven that purging occurs fewer times than it is compared to the other treatments.
And it doesn’t stop at that, Winlevi has some serious advantages compared to the old treatments. To be 100% clear all of these treatments do work but the side effects profile of taking Winlevi cream are far better than the treatments mentioned before. Also taking an oral pill is a treatment that is not safe for men while on the other hand, Winlevi cream is safe for them.
Of course, Winlevi topical treatment addresses the hormonal component as well but is proven to be safe for everyone except children under 12 years old. It is important to note also that this treatment was never tested on pregnant women so it is better to stay on the safe side and avoid it if you are pregnant.
When I say that Winlevi is a topical treatment this means that it is a treatment that is applied directly to the skin. Topical treatments are often preferred over oral medications because they can be more targeted and have fewer side effects. They can be in the form of creams, gels, or ointments. In the context of acne and their treatment, topical treatments can help to reduce the production of sebum and inflammation, leading to a decrease in acne lesions.
Another great advantage of Winlevi is that it has a very quick onset of action. This means that the long waiting period we all have been through with old treatments of acne of around 8 weeks is over. Winlevi gives results in as little as 3 weeks and the condition of the skin keeps improving for the next 5 to 6 weeks. This is quite the difference and advantage for Winlevi.
How Effective Is WINLEVI?
Clinical experience as well as clinical trials point to the efficacy of the topical class keteron for reducing the number of inflammatory acne lesions. These are acne lesions that are red, swollen, and painful. They are caused by inflammation in the skin and are often associated with more severe acne, such as papules, pustules, and nodules. When talking about clinical trials it is important how these trials were done.
Winlevi provided an improvement of 44.8% to 46.9% in the number of inflammatory lesions at 12 weeks. These were the results when the cream contained clascoterone ( the actual drug in Winlevi). But there were tests where they only applied the cream with other ingredients and without actual drug clascoterone and Winlevi still had 29.6% to 36.5% efficiency.
A study published in the Journal of Drugs in Dermatology in 2021 evaluated the effectiveness of clascoterone, the active ingredient in Winlevi, in the treatment of acne. The study included a total of 633 participants who were randomized to receive either clascoterone or a placebo cream. The results showed that clascoterone significantly reduced the number of inflammatory acne lesions after 12 weeks of treatment.
It is important to mention that these trials showed how using a cream/moisturizer alone can benefit acne and inflammation reduction. Of course, it is clear that having actual drugs inside of the cream furthers the benefits but I want you to keep this in mind.
How Does WINLEVI Compare To Tretinoin?
Both Retinol and Tretinoin, ingredients that are used in old acne treatments cause more purging than Winlevi does. Also when it comes to the efficiency of treating acne experiments have given slightly more favorable to Winlevi compared to tretinoin.
The experiments were done on people who were blindfolded so that they can know which treatment they were having for their acne. Overall the global assessment of the research investigators was slightly better for the Winlevi group but that was not statistically significant. It is important to note that this experiment was done over a period of 8 weeks.
So the Winlevi showed better results in that period but Tretinoin is known to reach its maximum potential only after 12 weeks sometimes even more.
Tretinoin has a lot of other benefits to the skin besides the treatment of acne, this includes improved collagen production, smoothing out wrinkles and fine lines, removing sun damage and it helps heal and prevent hyperpigmentation.
Unfortunately, Winlevi won’t have any of these „other“ benefits because it works the way I have described at the start of this text. So don’t think about Winlevi as something superior to Tretinoin globally.
Other Side Effects Of WINLEVI Besides Purging
- In theory Winlevi could lead to problems with blood pressure. I said this in theory because clinical trials have not shown the possibility of problems with blood pressure in the right dosage. So again, like with purging, most of the other side effects might occur only when you use too much of it. I would advise you to use only one gram of the drug twice a day on the affected areas.
- It can cause hpa axis suppression and the risks of this happening increase if you apply Winlevi under the occlusion. So for example, if you are using Winlevi on the face, you don’t want to use a pimple patch over it.
- It can increase the levels of potassium. Of course, only extremely high potassium level can cause a heart attack and requires immediate medical care. Studies have shown that 5% of tested people had an increase in their potassium levels.
- It can cause itchiness, redness, and irritation of the skin. All of these things are more likely to happen if you have sensitive skin.
To be very clear on this, this cream is very safe for the overall health of the body and all of these scenarios are rare.